Article
Obesity and peripheral arterial disease: A Mendelian Randomization analysis.
Atherosclerosis - 1 Apr 2016
Huang Ya, Xu Min, Xie Lan, Wang Tiange, Huang Xiaolin, Lv Xiaofei, Chen Ying, Ding Lin, Lin Lin, Wang Weiqing, Bi Yufang, Sun Yimin, Zhang Yifei, Ning Guang
Abstract excerpt
BACKGROUND AND AIMS: Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomization (MR) approach. METHODS: A MR analysis was performed in 11,477 community-dwelling adults aged...
Topics
- Adult
- Body Mass Index
- Chi-Square Distribution
- China
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Linear Models
- Logistic Models
- Mendelian Randomization Analysis