Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer.

doi:10.1101/gr.187823.114

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer.

Genome research - 1 Oct 2015

Forsberg Lars A, Rasi Chiara, Pekar Gyula, Davies Hanna, Piotrowski Arkadiusz, Absher Devin, Razzaghian Hamid Reza, Ambicka Aleksandra, Halaszka Krzysztof, Przewoźnik Marcin, Kruczak Anna, Mandava Geeta, Pasupulati Saichand, Hacker Julia, Prakash K Reddy, Dasari Ravi Chandra, Lau Joey, Penagos-Tafurt Nelly, Olofsson Helena M, Hallberg Gunilla, Skotnicki Piotr, Mituś Jerzy, Skokowski Jaroslaw, Jankowski Michal, Śrutek Ewa, Zegarski Wojciech, Tiensuu Janson Eva, Ryś Janusz, Tot Tibor, Dumanski Jan P

Abstract excerpt

Sporadic breast cancer (SBC) is a common disease without robust means of early risk prediction in the population. We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (uninvolved margin, UM) outside the primary tumor (PT). In total, 1162 UMs (1-14 per breast) were studied. Comparative analysis between UM(s), PT(s), and blood/skin from the same patient as a control is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cohort Studies

Share to DNA Mutational Analysis

Share to Gene Dosage

Share to Genes, erbB-2

Share to Receptor, ErbB-2

Share to Receptors, Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 26430163
DOI: 10.1101/gr.187823.114
PMCID: PMC4579338

Genes

ERBB2
EGFR
FGFR1
LIFR
NGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer.PMID 26430163Read ↗

Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients.Semantic proximity Read ↗

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.Semantic proximity Read ↗

Luminal breast epithelial cells from wildtype and <i>BRCA</i> mutation carriers harbor copy number alterations commonly associated with breast cancerSemantic proximity Read ↗

The landscape of cancer genes and mutational processes in breast cancer.Semantic proximity Read ↗

Subtypes of familial breast tumours revealed by expression and copy number profiling.Semantic proximity Read ↗

Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 MutationsSemantic proximity Read ↗

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing.Semantic proximity Read ↗

The topography of mutational processes in breast cancer genomes.Semantic proximity Read ↗

Somatic copy number alterations modulate tumor suppressor and oncogene expression to drive early onset of breast cancerSemantic proximity Read ↗

Somatic Genetic Aberrations in Benign Breast Disease and the Risk of Subsequent Breast CancerSemantic proximity Read ↗

Whole-genome landscapes of 1,364 breast cancers.Semantic proximity Read ↗

Molecular alterations in sporadic breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.