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Article

Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.

BMC medical genomics - 25 Jul 2015

Kumar Yogesh, Yang Jianfeng, Hu Taobo, Chen Lei, Xu Zhi, Xu Lin, Hu Xiao-Xia, Tang Gusheng, Wang Jian-Min, Li Yi, Poon Wai-Sang, Wan Weiqing, Zhang Liwei, Mat Wai-Kin, Pun Frank W, Lee Peggy, Cheong Timothy H Y, Ding Xiaofan, Ng Siu-Kin, Tsang Shui-Ying, Chen Jin-Fei, Zhang Peng, Li Shao, Wang Hong-Yang, Xue Hong

Abstract excerpt

BACKGROUND: The presence of loss-of-heterozygosity (LOH) mutations in cancer cell genomes is commonly encountered. Moreover, the occurrences of LOHs in tumor suppressor genes play important roles in oncogenesis. However, because the causative mechanisms underlying LOH mutations in cancer cells yet remain to be elucidated, enquiry into the nature of these mechanisms based on a comprehensive examination of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26208496
DOI: 10.1186/s12920-015-0104-2
PMCID: PMC4515014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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