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Article

Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel.

The Journal of molecular diagnostics : JMD - 1 May 2023

Glodzik Dominik, Selenica Pier, Rogge Ryan A, Silverman Ian M, Mandelker Diana, Harris Sam, Zhao Jianhua, Zinda Michael, Veloso Artur, Malani Nirav, Riaz Nadeem, Koehler Maria, Daber Robert D, Johnson Verity, Rimkunas Victoria, Reis-Filho Jorge S

Abstract excerpt

Patient selection for synthetic lethal-based cancer therapy may be improved by assessment of gene-specific loss of heterozygosity (LOH) and biallelic loss of function (LOF). This report describes SyNthetic lethal Interactions for Precision Diagnostics (SNiPDx), a targeted next-generation sequencing (NGS) panel for detection of LOH and biallelic LOF alterations in 26 target genes focused on DNA damage response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36944408
DOI: 10.1016/j.jmoldx.2023.02.004
PMCID: PMC10340082

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