Article
Forward and reverse mutations in stages of cancer development.
Human genomics - 22 Aug 2018
Hu Taobo, Kumar Yogesh, Shazia Iram, Duan Shen-Jia, Li Yi, Chen Lei, Chen Jin-Fei, Yin Rong, Kwong Ava, Leung Gilberto Ka-Kit, Mat Wai-Kin, Wu Zhenggang, Long Xi, Chan Cheuk-Hin, Chen Si, Lee Peggy, Ng Siu-Kin, Ho Timothy Y C, Yang Jianfeng, Ding Xiaofan, Tsang Shui-Ying, Zhou Xuqing, Zhang Dan-Hua, Zhou En-Xiang, Xu Lin, Poon Wai-Sang, Wang Hong-Yang, Xue Hong
Abstract excerpt
BACKGROUND: Massive occurrences of interstitial loss of heterozygosity (LOH) likely resulting from gene conversions were found by us in different cancers as a type of single-nucleotide variations (SNVs), comparable in abundance to the commonly investigated gain of heterozygosity (GOH) type of SNVs, raising the question of the relationships between these two opposing types of cancer mutations. METHODS: In the...
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