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Article

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons.

BMC cancer - 12 May 2010

Green Michael R, Jardine Paul, Wood Peter, Wellwood Jeremy, Lea Rod A, Marlton Paula, Griffiths Lyn R

Abstract excerpt

BACKGROUND: Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA samples. However, for many archival samples, patient-matched normal DNA is not available leading to the under-utilization of this important resource in LOH studies....

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Share to Chromosomes, Human, Pair 1
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 20462409
DOI: 10.1186/1471-2407-10-195
PMCID: PMC2885361

Genes

ETV3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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