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Article

Frequent loss of heterozygosity without loss of genetic material in acute myeloid leukemia with a normal karyotype.

Genes, chromosomes & cancer - 1 Nov 2005

Gorletta Tatiana Alessandra, Gasparini Patrizia, D'Elios Mario Milco, Trubia Maurizio, Pelicci Pier Giuseppe, Di Fiore Pier Paolo

Abstract excerpt

We performed a whole-genome loss of heterozygosity (LOH) analysis of 32 cases of acute myeloid leukemia with normal karyotype using high-density single nucleotide polymorphism arrays. LOH was found in 20% of cases. We identified two types of LOH: (i) interstitial, characterized by small deletions of genomic DNA (2-8 Mb), and (ii) terminal, involving large (30-90 Mb) telomeric regions. Surprisingly, terminal LOH...

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Identifiers

PMID: 16015648
DOI: 10.1002/gcc.20234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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