Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders

Abstract excerpt

Disulfide-rich peptides (DRPs), particularly those featuring the inhibitor cystine knot (ICK) motif, represent promising scaffolds for developing next-generation protein modulators and therapeutic agents due to their remarkable stability and specificity. However, their inherent structural integrity and lack of structural plasticity significantly limit their evolvability, creating a fundamental bottleneck in...

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