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Article

Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Oct 2015

Byrd James Brian, Auchus Richard J, White Perrin C

Abstract excerpt

BACKGROUND: A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. METHODS: The Dallas Heart Study is a large, multiethnic cohort with a high prevalence of hypertension. We genotyped 3452 Dallas Heart Study participants for -344C/T. Generalized linear models were used to assess whether variation at...

Topics

Adult
Cardiovascular Diseases
Cytochrome P-450 CYP11B2
Ethnicity
Female
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Phenotype

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 26200036
DOI: 10.1097/JIM.0000000000000220
PMCID: PMC5568080

Genes

DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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