Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure.

doi:10.1097/HJH.0000000000004080

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Article

Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure.

Journal of hypertension - 1 Sept 2025

Lidani Karita C F, Tomar Shubham, Mousavi Hossein, Buscaglia Robert, Michael Kirolos, Landry Alexander P, Dupuis Leonie, Michos Erin D, Morgan Erin S, Guo Xiuqing, Yao Jie, Lin Henry J, Rotter Jerome I, Post Wendy S, Tsimikas Sotirios, Trainor Patrick J, DeFilippis Andrew P

Abstract excerpt

OBJECTIVE: The renin angiotensin aldosterone system plays a key role in circulatory homeostasis. We sought to identify genetic determinants of measured plasma angiotensinogen levels and subsequently evaluate the association of these single nucleotide polymorphisms (SNPs) with blood pressure (BP) and hypertension in a multiethnic population. METHODS: Genome-wide association study (GWAS) of plasma angiotensinogen...

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PMID: 40552363
DOI: 10.1097/HJH.0000000000004080
PMCID: PMC12337919

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