Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor.

Journal of neuroimmunology - 15 Aug 2015

Williams Kimberly S, Killebrew Deirdre A, Clary Gillian P, Seawell Jaimie A, Meeker Rick B

Abstract excerpt

To characterize the role of neurotrophin receptors on macrophages, we investigated the ability of nerve growth factor (NGF) and its precursor, proNGF, to regulate human macrophage phenotype. The p75 neurotrophin receptor (p75(NTR)) and TrkA were concentrated within overlapping domains on membrane ruffles. NGF stimulation of macrophages increased membrane ruffling, calcium spiking, phagocytosis and growth factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Macrophages

Share to Nerve Growth Factor

Share to Protein Precursors

Share to Rats, Long-Evans

Source

Open in PubMed Open full text

Identifiers

PMID: 26198923
DOI: 10.1016/j.jneuroim.2015.05.016
PMCID: PMC4528983

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor.PMID 26198923Read ↗

Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV.Semantic proximity Read ↗

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types.Semantic proximity Read ↗

Retinoic acid increases phagocytosis of myelin by macrophages.Semantic proximity Read ↗

Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.Semantic proximity Read ↗

The dual nature of neurotrophins.Semantic proximity Read ↗

Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.Semantic proximity Read ↗

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.Semantic proximity Read ↗

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes.Semantic proximity Read ↗

Nerve Growth Factor and Pathogenesis of Leprosy: Review and UpdateSemantic proximity Read ↗

Nerve growth factor promotes TLR4 signaling-induced maturation of human dendritic cells in vitro through inducible p75NTR 1.Semantic proximity Read ↗

ProNGF inhibits NGF-mediated TrkA activation in PC12 cells.Semantic proximity Read ↗

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.