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Article

Angiotensin II promotes an osteoblast-like phenotype in porcine aortic valve myofibroblasts.

Aging clinical and experimental research - 1 Apr 2016

Xie Cuihong, Shen Yingnian, Hu Weilin, Chen Zhengping, Li Yongsheng

Abstract excerpt

OBJECTIVES: The mechanisms for pathogenesis of cardiac valve calcification were explored by studying the regulation of the Wnt signaling pathway during the transformation from cardiac valvular myofibroblasts to osteoblast-like phenotype. METHODS: Studies were carried on primary cultured porcine aortic valvular myofibroblasts. The cells were randomly divided into four groups and treated with angiotensin II (Ang...

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Source

Identifiers

PMID: 26197716
DOI: 10.1007/s40520-015-0408-2

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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