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Article

Parathyroid Hormone Induces Human Valvular Endothelial Cells Dysfunction That Impacts the Osteogenic Phenotype of Valvular Interstitial Cells.

International journal of molecular sciences - 29 Mar 2022

Vadana Mihaela, Cecoltan Sergiu, Ciortan Letitia, Macarie Razvan D, Mihaila Andreea C, Tucureanu Monica M, Gan Ana-Maria, Simionescu Maya, Manduteanu Ileana, Droc Ionel, Butoi Elena

Abstract excerpt

Parathyroid hormone (PTH) is a key regulator of calcium, phosphate and vitamin D metabolism. Although it has been reported that aortic valve calcification was positively associated with PTH, the pathophysiological mechanisms and the direct effects of PTH on human valvular cells remain unclear. Here we investigated if PTH induces human valvular endothelial cells (VEC) dysfunction that in turn could impact the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35409134
DOI: 10.3390/ijms23073776
PMCID: PMC8998852

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