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Article

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways.

Acta diabetologica - 1 Jun 2017

Rosa Mickael, Paris Camille, Sottejeau Yoann, Corseaux Delphine, Robin Emmanuel, Tagzirt Madjid, Juthier Francis, Jashari Ramadan, Rauch Antoine, Vincentelli André, Staels Bart, Van Belle Eric, Susen Sophie, Dupont Annabelle

Abstract excerpt

AIMS: Calcific aortic valve disease (CAVD) affects 2-6% of the population over 65 years, and age, gender, smoking, overweight, dyslipidemia, diabetes contribute to the development of this disease. CAVD results, in part, from the osteoblast differentiation of human valvular interstitial cells (VICs). This study aims to elucidate the effects of leptin on osteoblast phenotype of VICs and the signalling pathways...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28314924
DOI: 10.1007/s00592-017-0980-3

Genes

CAD
RUNX2

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