Article
Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016
Gomez-Stallons M Victoria, Wirrig-Schwendeman Elaine E, Hassel Keira R, Conway Simon J, Yutzey Katherine E
Abstract excerpt
OBJECTIVE: Calcific aortic valve disease (CAVD) is the most prevalent type of heart valve disease, affecting ≈2% of the US population. CAVD is characterized by the presence of calcific nodules, resulting in aortic valve (AoV) stenosis; however, the underlying mechanisms driving disease remain unknown. Studies of human diseased AoV provide initial evidence that bone morphogenetic protein (BMP) signaling, essential...
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