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Article

Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2016

Pentsova Elena I, Shah Ronak H, Tang Jiabin, Boire Adrienne, You Daoqi, Briggs Samuel, Omuro Antonio, Lin Xuling, Fleisher Martin, Grommes Christian, Panageas Katherine S, Meng Fanli, Selcuklu S Duygu, Ogilvie Shahiba, Distefano Natalie, Shagabayeva Larisa, Rosenblum Marc, DeAngelis Lisa M, Viale Agnes, Mellinghoff Ingo K, Berger Michael F

Abstract excerpt

PURPOSE: Cancer spread to the central nervous system (CNS) often is diagnosed late and is unresponsive to therapy. Mechanisms of tumor dissemination and evolution within the CNS are largely unknown because of limited access to tumor tissue. MATERIALS AND METHODS: We sequenced 341 cancer-associated genes in cell-free DNA from cerebrospinal fluid (CSF) obtained through routine lumbar puncture in 53 patients with...

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Identifiers

PMID: 27161972
DOI: 10.1200/JCO.2016.66.6487
PMCID: PMC4981784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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