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Cerebrospinal fluid tumor DNA for liquid biopsy in glioma patients' management: Close to the clinic?

Critical reviews in oncology/hematology - 1 Feb 2020

Simonelli Matteo, Dipasquale Angelo, Orzan Francesca, Lorenzi Elena, Persico Pasquale, Navarria Pierina, Pessina Federico, Nibali Marco Conti, Bello Lorenzo, Santoro Armando, Boccaccio Carla

Abstract excerpt

Cell-free circulating tumor DNA (ct-DNA) reflecting the whole tumor spatial and temporal heterogeneity currently represents the most promising candidate for liquid biopsy strategy in glioma. Unlike other solid tumors, it is now widely accepted that the best source of ct-DNA for glioma patients is the cerebrospinal fluid, since blood levels are usually low and detectable only in few cases. A cerebrospinal fluid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32005411
DOI: 10.1016/j.critrevonc.2020.102879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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