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HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus–Specific CD4 <sup>+</sup> T-Cell Responses

20 Jul 2016

Abstract excerpt

BACKGROUND: Each year dengue virus (DENV) infects 400 million human but causes symptomatic disease in only a subset of patients, suggesting that host genetic factors may play a role. HLA molecules that restrict T-cell responses are one of the most polymorphic host factors in humans. METHODS: Here we map HLA DRB1-restricted DENV-specific epitopes in individuals previously exposed to DENV, to identify the breadth...

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PMID: 27443615
DOI: 10.1093/infdis/jiw309

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