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Article

Cancer-associated TERT promoter mutations abrogate telomerase silencing.

eLife - 21 Jul 2015

Chiba Kunitoshi, Johnson Joshua Z, Vogan Jacob M, Wagner Tina, Boyle John M, Hockemeyer Dirk

Abstract excerpt

Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established. We used genome editing of human pluripotent stem cells with physiological telomerase expression to elucidate the mechanism by which these mutations contribute to human disease. Surprisingly, telomerase-expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26194807
DOI: 10.7554/eLife.07918
PMCID: PMC4507476

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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