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Article

The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway.

Journal of molecular biology - 15 Jul 2005

Koukaki Marina, Vlanti Anna, Goudela Sophia, Pantazopoulou Areti, Gioule Harris, Tournaviti Stella, Diallinas George

Abstract excerpt

UapA, a member of the NAT/NCS2 family, is a high affinity, high capacity, uric acid-xanthine/H+ symporter of Aspergillus nidulans. We have previously presented evidence showing that a highly conserved signature motif ([Q/E/P]408-N-X-G-X-X-X-X-T-[R/K/G])417 is involved in UapA function. Here, we present a systematic mutational analysis of conserved residues in or close to the signature motif of UapA. We show that...

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PMID: 15953615
DOI: 10.1016/j.jmb.2005.04.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway.PMID 15953615Read ↗

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