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Article

Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes.

Journal of molecular biology - 2 Nov 2001

Amillis S, Koukaki M, Diallinas G

Abstract excerpt

UapA, a highly specific uric acid-xanthine transporter in Aspergillus nidulans, is a member of a large family of nucleobase-ascorbate transporters conserved in all domains of life. We have investigated structure-function relationships in UapA, by studying chimeric transporters and missense mutations, and showed that specific polar or charged amino acid residues (E412, E414, Q449, N450, T457) on either side of an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11697902
DOI: 10.1006/jmbi.2001.5087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes.PMID 11697902Read ↗

The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway.Semantic proximity Read ↗

Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.Semantic proximity Read ↗

Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.Semantic proximity Read ↗

Mutational analysis and modeling reveal functionally critical residues in transmembrane segments 1 and 3 of the UapA transporter.Semantic proximity Read ↗

Stabilizing the heterologously expressed uric acid-xanthine transporter UapA from the lower eukaryote Aspergillus nidulans.Semantic proximity Read ↗

Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family.Semantic proximity Read ↗

Context-dependent Cryptic Roles of Specific Residues in Substrate Selectivity of the UapA Purine Transporter.Semantic proximity Read ↗

Substrate selectivity of YgfU, a uric acid transporter from Escherichia coli.Semantic proximity Read ↗

Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.Semantic proximity Read ↗

Distinct specific interactions of the UapA transporter with membrane lipids are critical for dimerization, ER-exit and functionSemantic proximity Read ↗

Mutational analysis of Phanerochaete chrysosporium´s purine transporter.Semantic proximity Read ↗

Structural and functional studies of the xanthine transporter UapA and the boric acid transporter Bor1Semantic proximity Read ↗

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