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Article

Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family.

PloS one - 1 Jan 2012

Kosti Vasiliki, Lambrinidis George, Myrianthopoulos Vassilios, Diallinas George, Mikros Emmanuel

Abstract excerpt

Using the crystal structure of the uracil transporter UraA of Escherichia coli, we constructed a 3D model of the Aspergillus nidulans uric acid-xanthine/H(+) symporter UapA, which is a prototype member of the Nucleobase-Ascorbate Transporter (NAT) family. The model consists of 14 transmembrane segments (TMSs) divided into a core and a gate domain, the later being distinctly different from that of UraA. By...

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Identifiers

PMID: 22848666
DOI: 10.1371/journal.pone.0041939
PMCID: PMC3405029

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Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family.PMID 22848666Read ↗

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