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Article

Mutational analysis of Phanerochaete chrysosporium´s purine transporter.

PloS one - 1 Jan 2024

Barraco-Vega Mariana, Sanguinetti Manuel, da Rosa Gabriela, Cecchetto Gianna

Abstract excerpt

We present here a mutational analysis of the purine transporter from Phanerochaete chrysosporium (PhZ), a member of the AzgA-like subfamily within the Nucleobase Ascorbate Transporters family. We identified key residues that determine its substrate specificity and transport efficiency. Thirteen PhZ mutants were generated and heterologously expressed in Aspergillus nidulans. The growth of mutant strains in the...

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Identifiers

PMID: 39480815
DOI: 10.1371/journal.pone.0313174
PMCID: PMC11527162

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