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Article

Context-dependent Cryptic Roles of Specific Residues in Substrate Selectivity of the UapA Purine Transporter.

Journal of molecular biology - 6 Aug 2021

Kourkoulou Anezia, Zantza Iliana, Foti Konstantina, Mikros Emmanuel, Diallinas George

Abstract excerpt

Members of the ubiquitous Nucleobase Ascorbate Transporter (NAT) family are H+ or Na+ symporters specific for the cellular uptake of either purines and pyrimidines or L-ascorbic acid. Despite the fact that several bacterial and fungal members have been extensively characterised at a genetic, biochemical or cellular level, and crystal structures of NAT members from Escherichia coli and Aspergillus nidulans have...

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PMID: 33497644
DOI: 10.1016/j.jmb.2021.166814

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Context-dependent Cryptic Roles of Specific Residues in Substrate Selectivity of the UapA Purine Transporter.PMID 33497644Read ↗

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