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Article

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.

Nature structural & molecular biology - 1 Aug 2015

Volkers Gesa, Worrall Liam J, Kwan David H, Yu Ching-Ching, Baumann Lars, Lameignere Emilie, Wasney Gregory A, Scott Nichollas E, Wakarchuk Warren, Foster Leonard J, Withers Stephen G, Strynadka Natalie C J

Abstract excerpt

Sialyltransferases of the mammalian ST8Sia family catalyze oligo- and polysialylation of surface-localized glycoproteins and glycolipids through transfer of sialic acids from CMP-sialic acid to the nonreducing ends of sialic acid acceptors. The crystal structure of human ST8SiaIII at 1.85-Å resolution presented here is, to our knowledge, the first solved structure of a polysialyltransferase from any species, and...

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PMID: 26192331
DOI: 10.1038/nsmb.3060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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