Article

Structural basis for the delivery of activated sialic acid into Golgi for sialyation

2019-03-17

Abstract excerpt

The decoration of secretory glycoproteins and glycolipids with sialic acid is critical to many physiological and pathological processes. Sialyation is dependent on a continuous supply of sialic acid into Golgi organelles in the form of CMP-sialic acid. Translocation of CMP-sialic acid into Golgi is carried out by the CMP-sialic acid transporter (CST). Mutations in human CST are linked to glycosylation disorders, a...

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Literature Corpus work: 1ce1efc1-6bd9-58f3-928a-2826e5ef0998
DOI: 10.1101/580449

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