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Article

Clinicopathologic implications of NF1 gene alterations in diffuse gliomas.

Human pathology - 1 Sept 2015

Vizcaíno M Adelita, Shah Smit, Eberhart Charles G, Rodriguez Fausto J

Abstract excerpt

Recent studies have identified somatic alterations in the gene encoding for neurofibromin (NF1) in a subset of glioblastoma (GBM), usually associated with the mesenchymal molecular subtype. To understand the significance of NF1 genetic alterations in diffuse gliomas in general, we evaluated public databases and tested for NF1 copy number alterations in a cohort using fluorescence in situ hybridization. NF1...

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Source

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Identifiers

PMID: 26190195
DOI: 10.1016/j.humpath.2015.05.014
PMCID: PMC4703095

Genes

IDH1
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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