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Article

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.

Genes, chromosomes & cancer - 1 Dec 2011

Beert Eline, Brems Hilde, Daniëls Bruno, De Wever Ivo, Van Calenbergh Frank, Schoenaers Joseph, Debiec-Rychter Maria, Gevaert Olivier, De Raedt Thomas, Van Den Bruel Annick, de Ravel Thomy, Cichowski Karen, Kluwe Lan, Mautner Victor, Sciot Raf, Legius Eric

Abstract excerpt

Benign peripheral nerve sheath tumors (PNSTs) are a characteristic feature of neurofibromatosis type I (NF1) patients. NF1 individuals have an 8-13% lifetime risk of developing a malignant PNST (MPNST). Atypical neurofibromas are symptomatic, hypercellular PNSTs, composed of cells with hyperchromatic nuclei in the absence of mitoses. Little is known about the origin and nature of atypical neurofibromas in NF1...

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PMID: 21987445
DOI: 10.1002/gcc.20921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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