Article
Neurofibromatosis-1 gene deletions and mutations in de novo adult acute myeloid leukemia.
American journal of hematology - 1 Apr 2013
Boudry-Labis Elise, Roche-Lestienne Catherine, Nibourel Olivier, Boissel Nicolas, Terre Christine, Perot Christine, Eclache Virginie, Gachard Nathalie, Tigaud Isabelle, Plessis Ghislaine, Cuccuini Wendy, Geffroy Sandrine, Villenet Céline, Figeac Martin, Leprêtre Frederic, Renneville Aline, Cheok Meyling, Soulier Jean, Dombret Hervé, Preudhomme Claude
Abstract excerpt
Germline heterozygous alterations of the tumor-suppressor gene neurofibromatosis-1 (NF1) lead to neurofibromatosis type 1, a genetic disorder characterized by a higher risk to develop juvenile myelomonocytic leukemia and/or acute myeloid leukemia (AML). More recently, somatic 17q11 deletions encompassing NF1 have been described in many adult myeloid malignancies. In this context, we aimed to define NF1...
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