Article

Somatic Genomic Defects And Tumor Progression In NF1-associated Tumors 

2021-01-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Neurofibromatosis type 1 (NF1) is a common inherited tumor predisposition syndrome. Many genetic and biochemical evidences considered<italic> NF1 </italic>gene<italic> </italic>as<italic> </italic>a tumor suppressor gene that inactivation of both <italic>NF1 </italic>alleles would lead to tumorigenesis. However, the clinical evaluation and early detection of mal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 429ccdff-2c9c-50ca-ae8e-fc8c6b439a15
DOI: 10.21203/rs.3.rs-144193/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic Genomic Defects And Tumor Progression In NF1-associated Tumors DOI 10.21203/rs.3.rs-144193/v1Read

A detailed landscape of genomic alterations in malignant peripheral nerve sheath tumor cell lines challenges the current MPNST diagnosisSemantic proximity Read

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read

Identification of Malignant Peripheral Nerve Sheath Tumor subtypes with distinct genomic identitiesSemantic proximity Read

Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors.Semantic proximity Read

Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1–associated atypical neurofibromasSemantic proximity Read

A Sequencing Overview of Malignant Peripheral Nerve Sheath Tumors: Findings and Implications for TreatmentSemantic proximity Read

Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosisSemantic proximity Read

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.Semantic proximity Read

Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1Semantic proximity Read

Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNASemantic proximity Read

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNASemantic proximity Read

Distinctive Epigenomic Alterations in NF1-deficient Cutaneous and Plexiform Neurofibromas Drive Differential MKK/p38 SignalingSemantic proximity Read