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Article

NF1-Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of NF1-Mutant Rhabdomyosarcoma and NF1-Associated Malignant Triton Tumor.

JCO precision oncology - 1 Apr 2024

de Traux de Wardin Henry, Dermawan Josephine K, Vanoli Fabio, Jiang Samuel C, Singer Samuel, Chi Ping, Tap William, Wexler Leonard H, Antonescu Cristina R

Abstract excerpt

PURPOSE: Alterations of the NF1 tumor suppressor gene is the second most frequent genetic event in embryonal rhabdomyosarcoma (ERMS), but its associations with clinicopathologic features, outcome, or coexisting molecular events are not well defined. Additionally, NF1 alterations, mostly in the setting of neurofibromatosis type I (NF1), drive the pathogenesis of most malignant peripheral nerve sheath tumor with...

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Source

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Identifiers

PMID: 38603649
DOI: 10.1200/PO.23.00597
PMCID: PMC11161258

Genes

NF1
TP53
CDKN2A
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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