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Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.

Neurobiology of aging - 1 Oct 2014

Jiao Bin, Liu Xiaoyan, Tang Beisha, Hou Lihua, Zhou Lin, Zhang Fufeng, Zhou Yafang, Guo Jifeng, Yan Xinxiang, Shen Lu

Abstract excerpt

Recently, 3 rare coding variants significantly associated with Alzheimer's disease (AD) risk have been identified in western populations using whole exome sequencing method, including p.R47H in TREM2, p.V232M in PLD3, and p.T835M in UNC5C. To examine whether these variants are genetic risk factors in patients with AD from mainland China, we sequenced exon 2 of TREM2, exon 9 of PLD3, and exon 15 of UNC5C in...

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Source

Identifiers

PMID: 24866402
DOI: 10.1016/j.neurobiolaging.2014.04.025

Genes

TREM2
PLD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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