Article
Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.
Journal of medical genetics - 1 Jan 2016
Kwong Ava, Shin Vivian Y, Ho John C W, Kang Eunyoung, Nakamura Seigo, Teo Soo-Hwang, Lee Ann S G, Sng Jen-Hwei, Ginsburg Ophira M, Kurian Allison W, Weitzel Jeffrey N, Siu Man-Ting, Law Fian B F, Chan Tsun-Leung, Narod Steven A, Ford James M, Ma Edmond S K, Kim Sung-Won
Abstract excerpt
Approximately 5%-10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations. Some mutations are unique to one family and others are recurrent; the spectrum of BRCA1/BRCA2 mutations varies depending on the geographical origins, populations or ethnic groups. In this review, we compiled data from 11 participating Asian countries...
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