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Article

Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population.

International journal of cancer - 15 Mar 2023

Qin Zixin, Li Jiaheng, Tam Benjamin, Sinha Siddharth, Zhao Bojin, Bhaskaran Shanmuga Priya, Huang Teng, Wu Xiaobing, Chian Jia Sheng, Guo Maoni, Kou Si Hoi, Lei Huijun, Zhang Li, Wang Xiaoyu, Lagniton Philip Naderev P, Xiao Fengxia, Jiang Xinyang, Wang San Ming

Abstract excerpt

Pathogenic variation in BRCA1 and BRCA2 (BRCA) causes high risk of breast and ovarian cancer, and BRCA variation data are important markers for BRCA-related clinical cancer applications. However, comprehensive BRCA variation data are lacking from the Asian population despite its large population size, heterogenous genetic background and diversified living environment across the Asia continent. We performed a...

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Asia
Asian
Asian People
BRCA1 Protein
Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Germ-Line Mutation

Ovarian Neoplasms

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Identifiers

PMID: 36385461
DOI: 10.1002/ijc.34359
PMCID: PMC10098510

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