Mutation Spectrum Analysis of BRCA1/2 Genes for Hereditary Breast and Ovarian Cancer in the Indian Population.

doi:10.31557/APJCP.2024.25.12.4145

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Article

Mutation Spectrum Analysis of BRCA1/2 Genes for Hereditary Breast and Ovarian Cancer in the Indian Population.

Asian Pacific journal of cancer prevention : APJCP - 1 Dec 2024

Lila Kunjal, Bhanushali Harshita, Chanekar MIlind, Jatale Raj, Banerjee Monisha, Dixit Rakhi Bajpai, Rajadhyaksha Aparna, Chadha Kirti

Abstract excerpt

OBJECTIVE: The objective of this study was to determine the prevalence and spectrum of genetic mutations linked to inherited breast and ovary cancer (HBOC) in the Indian population, and to evaluate the correlation of BRCA mutation types, frequency, and incidence with age, gender, and personal and family history. METHODS: A retrospective cohort of 500 Indian HBOC patients, meeting NCCN criteria who underwent...

Topics

Humans
Female
Retrospective Studies
BRCA1 Protein
BRCA2 Protein
India
Middle Aged
Adult
Genetic Predisposition to Disease
Ovarian Neoplasms
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Breast Neoplasms

Prognosis

Follow-Up Studies

Biomarkers, Tumor

High-Throughput Nucleotide Sequencing

Aged

Hereditary Breast and Ovarian Cancer Syndrome

Source

Open in PubMed

Identifiers

PMID: 39733403
DOI: 10.31557/APJCP.2024.25.12.4145

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