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Spectrum of BRCA1/2 pathogenic variants in Southern and Western Asia-a systematic review.

Mutation research. Reviews in mutation research - 1 Jan 2025

Khan Samra, Burney Ikram A, Nasir Mahrukh, Saleem Humaira, Irfan Muhammad, Shakeel Muhammad, Khan Ishtiaq Ahmad

Abstract excerpt

BRCA1/2 germline variants account for 5-10 % of breast cancers (BC) or up to 25 % of hereditary breast cancers, yet data on their prevalence in South Asia and the Middle East remains limited. This study investigates germline BRCA1/2 pathogenic variants (PVs) in eight South Asian Association for Regional Cooperation (SAARC) and six Gulf Cooperation Council (GCC) countries, providing insights into the regional...

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BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
BRCA1 gene
BRCA2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Germ-Line Mutation

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Identifiers

PMID: 40543723
DOI: 10.1016/j.mrrev.2025.108549

Genes

BRCA1
BRCA2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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