Article
Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients.
Gynecologic oncology - 1 May 2016
Hasmad Hanis Nazihah, Lai Kah Nyin, Wen Wei Xiong, Park Daniel Jonathan, Nguyen-Dumont Tú, Kang Peter Choon Eng, Thirthagiri Eswary, Ma'som Mahirah, Lim Boon Kiong, Southey Melissa, Woo Yin Ling, Teo Soo-Hwang
Abstract excerpt
OBJECTIVE: Despite the discovery of breast and ovarian cancer predisposition genes BRCA1 and BRCA2 more than two decades ago, almost all the available data relate to women of European ancestry, with only a handful of studies in Asian populations. In this study, we determined the frequency of germline alterations in BRCA1 and BRCA2 in ovarian cancer patients from a multi-ethnic cross-sectional cohort of Asian...
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