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Article

Characterization of BRCA1 and BRCA2 variants in multi-ethnic Asian cohort from a Malaysian case-control study.

BMC cancer - 22 Feb 2017

Lai Kah Nyin, Ho Weang Kee, Kang In Nee, Kang Peter Choon Eng, Phuah Sze Yee, Mariapun Shivaani, Yip Cheng-Har, Mohd Taib Nur Aishah, Teo Soo-Hwang

Abstract excerpt

BACKGROUND: Genetic testing for BRCA1 and BRCA2 has led to the accurate identification of individuals at higher risk of cancer and the development of new therapies. Approximately 10-20% of the genetic testing for BRCA1 and BRCA2 leads to the identification of variants of uncertain significance (VUS), with higher proportions in Asians. We investigated the functional significance of 7 BRCA1 and 25 BRCA2 variants in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28222693
DOI: 10.1186/s12885-017-3099-6
PMCID: PMC5320733

Genes

BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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