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A comprehensive reference for BRCA1/2 genes pathogenic variants in Iran: published, unpublished and novel.

Familial cancer - 1 Apr 2022

Majidzadeh-A Keivan, Zarinfam Shiva, Abdoli Nasrin, Yadegari Fatemeh, Esmaeili Rezvan, Farahmand Leila, Teimourzadeh Azin, Taghizadeh Mahdieh, Salehi Mansoor, Zamani Mohamad

Abstract excerpt

BRCA1 and BRCA2 are two prominent genes that account for about 20-40% of inherited breast cancer. Mutations in these genes are often associated with clustering of especially early-onset cancers in the family. The spectrum of BRCA variants showed a significant difference between geographic regions and ethnicities. The frequency and spectrum of BRCA mutations in Iran, a country in southwest Asia, have not yet been...

Topics

BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Iran

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ovarian Neoplasms

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Identifiers

PMID: 33754277
DOI: 10.1007/s10689-021-00242-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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