Article
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.
Circulation research - 16 Feb 2018
Mitchell Jane A, Knowles Rebecca B, Kirkby Nicholas S, Reed Daniel M, Edin Matthew L, White William E, Chan Melissa V, Longhurst Hilary, Yaqoob Magdi M, Milne Ginger L, Zeldin Darryl C, Warner Timothy D
Abstract excerpt
RATIONALE: The balance between vascular prostacyclin, which is antithrombotic, and platelet thromboxane A2, which is prothrombotic, is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed after the concerted actions of cPLA2α (cytosolic phospholipase A2) and COX (cyclooxygenase). Urinary 2,3-dinor-6-keto-PGF1α (PGI-M) and 11-dehydro-TXB2 (TX-M) have been taken as biomarkers of...
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