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Article

ALOX12 mutation in a family with dominantly inherited bleeding diathesis.

Journal of human genetics - 1 Aug 2021

Mitsui Tetsuo, Makino Satoshi, Tamiya Gen, Sato Hiroko, Kawakami Yuki, Takahashi Yoshitaka, Meguro Toru, Izumino Hiroko, Sudo Yosuke, Norota Ikuo, Ishii Kuniaki, Hayasaka Kiyoshi

Abstract excerpt

The arachidonic acid (AA) cascade plays a significant role in platelet aggregation. AA released from membrane phospholipids is metabolized by cyclooxygenase (COX) pathway to thromboxane A2 (TXA2) or by 12S-lipoxygenase (ALOX12) to 12-hydroperoxyeicosatetraenoic acid (12-HPETE). In contrast to a well-known role of the COX pathway in platelet aggregation, the role of ALOX12 is not well understood. Platelets of...

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Share to Arachidonate 12-Lipoxygenase
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Share to Blood Coagulation Disorders, Inherited

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PMID: 33564083
DOI: 10.1038/s10038-020-00887-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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