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Article

Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency.

Thrombosis and haemostasis - 1 Dec 2014

Faioni E M, Razzari C, Zulueta A, Femia E A, Fenu L, Trinchera M, Podda G M, Pugliano M, Marongiu F, Cattaneo M

Abstract excerpt

Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin-sister with early-onset bleeding diathesis and recurrent gastro-intestinal (GI) ulcers. Platelet aggregation/δ-granules secretion by collagen was impaired,...

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Identifiers

PMID: 25102815
DOI: 10.1160/TH14-04-0352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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