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Article

Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1.

Bioscience reports - 17 Mar 2015

Spiller Michael P, Guo Liang, Wang Qi, Tran Peter, Lu Hui

Abstract excerpt

Translocase of IM (inner membrane; Tim)9 and Tim10 are essential homologue proteins of the mitochondrial intermembrane space (IMS) and form a stable hexameric Tim9-Tim10 complex there. Redox-switch of the four conserved cysteine residues plays a key role during the biogenesis of these proteins and, in turn, the Tim proteins play a vital chaperone-like role during import of mitochondrial membrane proteins....

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Identifiers

PMID: 26182355
DOI: 10.1042/BSR20150038
PMCID: PMC4438305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1.PMID 26182355Read ↗

Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import.Semantic proximity Read ↗

Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10.Semantic proximity Read ↗

Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells.Semantic proximity Read ↗

Assembly of the mitochondrial Tim9-Tim10 complex: a multi-step reaction with novel intermediates.Semantic proximity Read ↗

Functional crosstalk between the carrier translocase machinery and YME1 complex maintains mitochondrial proteostasis and integritySemantic proximity Read ↗

Intramolecular disulfide bond of Tim22 protein maintains integrity of the TIM22 complex in the mitochondrial inner membrane.Semantic proximity Read ↗

Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space.Semantic proximity Read ↗

Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria.Semantic proximity Read ↗

Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion.Semantic proximity Read ↗

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space.Semantic proximity Read ↗

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.Semantic proximity Read ↗

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria.Semantic proximity Read ↗

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