Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells.

doi:10.1016/j.jmb.2007.06.025

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Article

Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells.

Journal of molecular biology - 31 Aug 2007

Vergnolle Mailys A S, Alcock Felicity H, Petrakis Nikos, Tokatlidis Kostas

Abstract excerpt

The Saccharomyces cerevisiae TIM10 complex (TIM10c) is an ATP-independent chaperone of the mitochondrial intermembrane space, involved in transport of polytopic membrane proteins. The complex is an alpha(3)beta(3) hexamer of Tim9 and Tim10 subunits. We have generated specific mutations in charged residues in the central core domain of each subunit delineated by the characteristic twin CX(3)C motif, and...

Topics

Adenosine Triphosphate
Amino Acid Motifs
Amino Acid Sequence
Genetic Complementation Test
Membrane Proteins
Membrane Transport Proteins
Mitochondria
Mitochondrial Membrane Transport Proteins
Mitochondrial Precursor Protein Import Complex Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondrial Proteins

Molecular Chaperones

Molecular Sequence Data

Mutation

Protein Structure, Tertiary

Protein Transport

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 17618651
DOI: 10.1016/j.jmb.2007.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mutation of conserved charged residues in mitochondrial TIM10 subunits precludes TIM10 complex assembly, but does not abolish growth of yeast cells.PMID 17618651Read ↗

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