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Article

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2015

Agelopoulos Konstantin, Richter Günther H S, Schmidt Eva, Dirksen Uta, von Heyking Kristina, Moser Benjamin, Klein Hans-Ulrich, Kontny Udo, Dugas Martin, Poos Kathrin, Korsching Eberhard, Buch Thorsten, Weckesser Matthias, Schulze Isabell, Besoke Regina, Witten Anika, Stoll Monika, Köhler Gabriele, Hartmann Wolfgang, Wardelmann Eva, Rossig Claudia, Baumhoer Daniel, Jürgens Heribert, Burdach Stefan, Berdel Wolfgang E, Müller-Tidow Carsten

Abstract excerpt

PURPOSE: A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at low frequency. EXPERIMENTAL DESIGN: Tumor...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

Identifiers

PMID: 26179511
DOI: 10.1158/1078-0432.CCR-14-2744

Genes

FGFR1
LAMB4
SLFN11
STAG2
UNC80
ZNF98

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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