The genomic landscape of pediatric Ewing sarcoma.

doi:10.1158/2159-8290.CD-13-1037

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Article

The genomic landscape of pediatric Ewing sarcoma.

Cancer discovery - 1 Nov 2014

Crompton Brian D, Stewart Chip, Taylor-Weiner Amaro, Alexe Gabriela, Kurek Kyle C, Calicchio Monica L, Kiezun Adam, Carter Scott L, Shukla Sachet A, Mehta Swapnil S, Thorner Aaron R, de Torres Carmen, Lavarino Cinzia, Suñol Mariona, McKenna Aaron, Sivachenko Andrey, Cibulskis Kristian, Lawrence Michael S, Stojanov Petar, Rosenberg Mara, Ambrogio Lauren, Auclair Daniel, Seepo Sara, Blumenstiel Brendan, DeFelice Matthew, Imaz-Rosshandler Ivan, Schwarz-Cruz Y Celis Angela, Rivera Miguel N, Rodriguez-Galindo Carlos, Fleming Mark D, Golub Todd R, Getz Gad, Mora Jaume, Stegmaier Kimberly

Abstract excerpt

UNLABELLED: Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the most genetically normal cancers characterized to date, with only EWS-ETS...

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Identifiers

PMID: 25186949
DOI: 10.1158/2159-8290.CD-13-1037

Genes

STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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