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Article

Nepro is localized in the nucleolus and essential for preimplantation development in mice

14 Jul 2015

Abstract excerpt

We generated knockout (KO) mice of Nepro, which has been shown to be necessary to maintain neural progenitor cells downstream of Notch in the mouse developing neocortex by using knockdown experiments, to explore its function in embryogenesis. Nepro KO embryos were morphologically indistinguishable from wild type (WT) embryos until the morula stage but failed in blastocyst formation, and many cells of the KO...

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PMID: 26178919
DOI: 10.1111/dgd.12232

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