Article
The integrator complex is required for integrity of Cajal bodies.
Journal of cell science - 1 Jan 2012
Takata Hideaki, Nishijima Hitoshi, Maeshima Kazuhiro, Shibahara Kei-ichi
Abstract excerpt
The nucleus in eukaryotic cells is a highly organized and dynamic structure containing numerous subnuclear bodies. The morphological appearance of nuclear bodies seems to be a reflection of ongoing functions, such as DNA replication, transcription, repair, RNA processing and RNA transport. The integrator complex mediates processing of small nuclear RNA (snRNA), so it might play a role in nuclear body formation....
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