Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.

Developmental biology - 1 Mar 2022

Petit Fabrice G, Jamin Soazik P, Kernanec Pierre-Yves, Becker Emmanuelle, Halet Guillaume, Primig Michael

Abstract excerpt

The conserved 3'-5' exoribonuclease EXOSC10/Rrp6 is required for gametogenesis, brain development, erythropoiesis and blood cell enhancer function. The human ortholog is essential for mitosis in cultured cancer cells. Little is known, however, about the role of Exosc10 during embryo development and organogenesis. We generated an Exosc10 knockout model and find that Exosc10-/- mice show an embryonic lethal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Blastomeres
Share to Cell Nucleolus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Exoribonucleases

Share to Exosome Multienzyme Ribonuclease Complex

Share to Ribosomes

Share to RNA Processing, Post-Transcriptional

Source

Identifiers

PMID: 34965385
DOI: 10.1016/j.ydbio.2021.12.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.PMID 34965385Read ↗

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transitionSemantic proximity Read ↗

RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.Semantic proximity Read ↗

A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation.Semantic proximity Read ↗

Biallelic variants in the RNA exosome gene <i>EXOSC5</i> are associated with developmental delays, short stature, cerebellar hypoplasia and motor weaknessSemantic proximity Read ↗

A Biallelic Variant of the RNA Exosome Gene<i>EXOSC4</i>Causes Translational Defects Associated with a Neurodevelopmental DisorderSemantic proximity Read ↗

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.Semantic proximity Read ↗

A <i>Drosophila</i> Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in NeuronsSemantic proximity Read ↗

Biallelic protein truncating <i>EXOSC6</i> variants cause a neurodevelopmental disorder with cerebellar atrophy, ataxia, and global developmental delaySemantic proximity Read ↗

The RNA exosome and RNA exosome-linked disease.Semantic proximity Read ↗

Medaka dead end encodes a cytoplasmic protein and identifies embryonic and adult germ cellsSemantic proximity Read ↗

Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.Semantic proximity Read ↗

Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.