Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

PloS one - 1 Jan 2012

Castellano-Pozo Maikel, García-Muse Tatiana, Aguilera Andrés

Abstract excerpt

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Size
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Checkpoints

Share to DNA Damage

Share to DNA Replication

Share to Mitosis

Share to Multiprotein Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 23285047
DOI: 10.1371/journal.pone.0052447
PMCID: PMC3527488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.PMID 23285047Read ↗

The THO complex as a key mRNP biogenesis factor in development and cell differentiation.Semantic proximity Read ↗

C. elegans nucleostemin is required for larval growth and germline stem cell division.Semantic proximity Read ↗

The THO complex in Schizosaccharomyces pombe-dissecting the composition and functional hierarchy.Semantic proximity Read ↗

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in <i>C. elegans</i>Semantic proximity Read ↗

EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis.Semantic proximity Read ↗

p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex.Semantic proximity Read ↗

Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.Semantic proximity Read ↗

Germ granule compartments coordinate specialized small RNA productionSemantic proximity Read ↗

TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in <i>C. elegans</i>Semantic proximity Read ↗

The TRIM-NHL protein LIN-41 and the OMA RNA-binding proteins antagonistically control the prophase-to-metaphase transition and growth of Caenorhabditis elegans oocytes.Semantic proximity Read ↗

The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.Semantic proximity Read ↗

A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.